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HPLC法测定盐酸特拉唑嗪片中盐酸特拉唑嗪的含量

Determination of terazosin hydrochloride in terazosin hydrochloride tablets by HPLC
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摘要 建立了盐酸特拉唑嗪片中盐酸特拉唑嗪的含量测定的HPLC内标法。以盐酸阿夫唑嗪作为内标,采用Alltima-CN柱,流动相为0.05mol·L-1NaH2PO4溶液(0.5mol·L-1的NaOH溶液调pH值至5.0)-甲醇(65:35);检测波长:246nm。结果表明:盐酸特拉唑嗪在5-50μg·mL-1的范围内呈良好的线形关系。回收率为99.6%,RSD=1.1%,N=9。 To establish a internal standard HPLC method for the determination of terazosin hydrochloride in terazosin hydrochloride tablets. Alfuzosin hydrochloride was used as internal standard, An alltima - CN column was used with 0.05 mol · L ^- 1 Nail2 po4 ( pH 5.0, adjusted with 0.5 mol · L^ - 1 NaOH) - methanol (65: 35 ) as mobile phase, detected at a wavelength of 244nm. Terazosin hydrochloride was showed good linearity in the concentration of 5 -50μg · mL^-1 , the average recovery was 99.6% with RSD of 1.1%.
作者 王守箐
机构地区 临沂师范学院
出处 《化学工程师》 CAS 2006年第10期34-35,共2页 Chemical Engineer
关键词 盐酸特拉唑嗪片 盐酸特拉唑嗪 盐酸阿夫唑嗪 高效液相色谱 terezosin hydrochloride tablets terazosin hydrochloride alfuzosin hydrochloride HPLC
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  • 1[1]Salva P,Bianchetti G,Morselli P,et al.Pharmacokinet ics of alfuzosin after single oral administration to heal thy volunteers,of three different doses[J ] .Biopharm Drug Dispos, 1992,13: 583.

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