血管对损伤的增生性反应：血管成形术后再狭窄犬模型的建立

The response of the vessel to the injury:A canine restenotic model after PTCAestablished

本文旨在探讨用犬建立一种实用性ＰＴＣＡ术后再狭窄模型的可行性及其可能矾制。２６条家犬的１４条冠状动脉、２４条股动脉内用大于血管直径１．５～２．０ｍｍ的球囊，在高压（１２１５．９～１４１８．５ｋＰａ）下置入长１５ｍｍ，直径３．０～３．５ｍｍ的不锈钢丝支架，有意造成明显的创伤。结果发现，在第四周内膜明显增厚，管腔百分狭窄面积在５０％以上，组织病理特征与人类ＰＴＣＡ术后再狭窄比较接近，病理改变与小猪模型基本一致。为防治再狭窄提供了方便实用的动物模型。

The efforts to reduce or eliminate restenosis after PTCA have been hampered by the lack of an ac-curate animal restenotic model with substational proliferation,This study was thus designed to determine theprobabilities and the mechanisms of developing a practical proliferative canine model by using deep injury tothe media of the coronary and femoral artery.Stainless steel wire coils were delivered percutaneously to the14 coronary and 24 femoral arteries in 26 canines with a oversized,high-pressure(1 215.9～141 8.5 kPa )balloon and were left in situ from 1,7,14,30,60 to 90 days. Histopathologic examinations was made afterangiograghy.The histologic examination showed that the substantional neointimal proliferation occured in 4～12 weeks with a lulninal narrow area more than 50%at least;the severity of the vessel injury-the mean in-jury score strongly correlated with neointimal thickness(r=0.862)and percent area setenosis(P<0.05),and the histopathologic results in femoral arteries were the same as those in coronary arteries.Our results in-dicated that this model is a practical and inexpensive one,and the histopathologic features of the proliferativeresponse were identical to those observed in human caces of restenosis after angioplasty.