白塞病患者血清抗PPD抗体测定及意义

The clinical significance of serum anti-PPD antibody determination in Behcet’S disease

本文用ＥＬＩＳＡ法对４４例白塞病（ＢＤ）患者和９０份对照组血清行抗结核菌素纯蛋白衍生物抗体（Ａ─ＰＰＤ）测定，结果发现１８例（４０．９１％）ＢＤ患者ＯＤ值高于正常，均值为０．２７９±０．１２５（（ＯＤ）；而３０例其他结缔组织病（包括系统性红斑狼疮，类风湿关节炎，强直性脊柱炎和赖特病）和６０例健康人对照组的均值分别为０．２０３±０．０８９（ＯＤ）和０．１４６±０．０７９（ＯＤ），与ＢＤ组比较差异有极显著性意义（Ｐ＜０．０１）。４４例ＢＤ组的临床观察发现２０例（４５．４５％）结核菌素皮试呈强阳性反应，与Ａ─ＰＰＤ测定具有极显著的一致性（Ｐ＜０．０１）。提示结核杆菌感染可能是ＢＤ发病原因之一，血清Ａ─ＰＰＤ测定有助于寻找病因，指导治疗。

This study was performed to evaluate the relationship between the infection of tubercle bacillus(TB)and Behcet’s disease.Serum anti-purified protein derivative antibody(A-PPD)was determined in 44 cases with BD,30 cases with Connective Tissue Disease(CTD)(including systemic lupus erytematosus,rheumatoid arthritis,ankylosing spondylitis,adult onset still’S disease)and 60 healthy controls(HC)by EI,ISA,The results showed a higher positive rate of A-PPD in BD group(41%)than those of the CTD group(6.66%)and HC group(0%)(P<0.01),We also found the strong positive results of tuberculin skin tests appeared in 20(45%)cases with BD.Among them,16(36%)cases presented clinical active tuberculo-sis or had history of tuberculosis.The good efficacy of anti-tuberculosis drugs were observed in 22(50%)cases with BD.We conclude that infection of TB rnay be one of the etiological factors of BD.