开博通、硝苯啶对原发性高血压患者血浆内皮素、肾素─血管紧张素─醛固酮系统的影响

The effects of capoten and nifedipine on plasma endothelin,renin activity,an-giotensin and aldosterone in patients with essential hypertension

本文对２４例原发性高血压（ＥＨ）患者随机分为应用升博通组及硝苯啶组，各１２例，均进行１４ｄ治疗，探讨这两种药物对血浆内皮素（ＦＴ）、肾素（ＰＲＡ）、皿管紧张素Ⅱ（ＡＴⅡ）及醛固酮（ＡＬＤ）系统、血压和心率的影响。结果表明：ＥＨ患者治疗前血浆ＦＴ、ＰＲＡ、ＡＴⅡ及ＡＬＤ浓度与正常对照组相比差异有显著性意义（Ｐ＜Ｏ．０１和Ｐ＜０．０５）．开博通组治疗后，血浆ＡＴⅡ、ＡＬＤ、血压及心率平均值与治疗前相比差异有显著性意义（Ｐ＜０．０１和Ｐ＜０．０５），ＦＴ和ＰＲＡ差异无显著意义（Ｐ＞０．０５）；硝苯啶组治疗后血浆ＥＴ、血压平均值与治疗前相比差异有极显著性意义（Ｐ＜０．０１）、ＡＴⅡ、ＡＬＤ虽有下降但差异无显著性意义（Ｐ＞０．０５），心率平均值增加（Ｐ＜０．０１）。以上两种药物从不同作用机制影响血管活性物质的皿浆浓度来降低血压，提示将此两种药物联合使用，呵更有效地发挥降压效果。

Twenty four patients with essential hypertension(EH)were treated for two weeks with capoten(group C 12 cases)or nifedipine(groLip N 12 cases).The results showed that that before treatment,the plasmalevels of endothelin(ET),renin activity(PRA),angiotensin Ⅱ(AT Ⅱ)and aldosterone(ALD)in patientswith EH were signiflcantly higher than those in normal ctintrols(P<001 and P>0. 05),after treatment,the level,of AT Ⅱ,ALD and mBP and mHR in group C decreased significantly(P<0.01 and P<0.05)ascompared with pre-treatment,but the plasma levels of FT and PRA had no significant difference(P<0.05).After treatment the levels of ET and mBP in group N were lower than before treatment(P<0.01.respective-ly);the plasma levels of AT and ALD decreased slightly,without significant difference as compared with be-fore treatment(P>0.05);mHR increased significantly than hefore treatment(P<0.01).It suggests thatthese two drugs are capable of different hypotensive mechanisms,and they may play a better role if used to-gether.