醒脑静滴丸的成型工艺研究

Study on preparation process and shaping operation of Xingnaojing Dropping Pills

目的探索醒脑静处方制成滴丸的工艺路线及质量控制。方法通过滴丸成型工艺研究、释放度测定;筛选出较优的制剂工艺、滴丸辅料;并对滴丸之质量进行初步评价。结果通过β糊精包合技术的使用,使得醒脑静处方各易挥发性成分制成包合物,组份与聚乙二醇4000:聚乙二醇6000(3:7)制成稳定的滴丸;物料与基质比例为1:1.8,滴丸成型率、硬度、溶散指标均满足要求。结论本工艺简明可行,药物有效成分释放迅速,适于开发醒脑静滴丸剂型。

Objective To ascertain the shaping β-cyclodextrin was applied to optimize the operation of 7）is optimal bases.Conclusion The references to develop a new preparation operation of Xingnaojing dropping pills.Methods Xingnaojing Xingnaojing dropping pills of Xingnaojing. pills.Results PEG4000 and PEG6000（3： has ideal quick-release ,which give