帕罗西汀与阿米替林治疗躯体化障碍的疗效比较

Comparison between paroxetine and amitriptyline in the treatment of somatization disorder

目的比较帕罗西汀与阿米替林治疗躯体化障碍的疗效和不良反应。方法81例躯体化障碍患者随机分成2组,分别用帕罗西汀与阿米替林治疗8 wk。用症状自评量表(SCL-90)中的躯体化、抑郁和焦虑3个因子总分评定症状变化,用不同减分率评定疗效。用不良反应量表(TESS)评定药物不良反应。结果帕罗西汀组痊愈率为61.90%,总有效率为90.48%;阿米替林的痊愈率为43.59%,总有效率为71.79%,2组疗效比较差异有统计学意义(P<0.05)。2组TESS测评,各时点组间比较,差异有统计学或高度统计学意义(P<0.05或P<0.01)。结论帕罗西汀治疗躯体化障碍疗效确切,不良反应较小。

AIM To compare the therapeutic effects and adverse drug reactions between paroxefine and amitriptyline in the treatment of somatization disorder. METHODS Eighty-one patients with somatization disorder were randomized into 2 groups, which were treated with paroxetine or amitriptyline for 8 wk. The symptomatic changes were evaluated using the total score of somatization, depression, and anxiety as described in symptom chek-list 90（SCL-90）, the thempeutic effect was assessed using various subtraction rotes, and drug-related adverse drug reactions were evaluated using the treatment emergent symptom scale （TESS）. RESULTS The recovery rate was 61.90% in the paroxefine treatment group and 43.59% in the amitriptyline treatment group, and the total effective rate was 90.48% and 71.79%, respectively. The difference in the efficacy between 2 groups was significant （ P 〈 O. 05）. TESS tests revealed that there were significant differences between 2 groups at various time points. CONCLUSION Paroxetine is effective in the treatment of somatization disorders, but has few adverse drug reactions.