6574例次地高辛血药浓度监测结果分析

Analysis of serum concentration of digoxin in 6 574 samples

目的通过对本院1988年至2003年地高辛血药浓度监测结果分析，为临床合理用药提供参考。方法采用FPIA法测定地高辛血药浓度，对3884例患者的6574例次血药浓度监测结果进行比较分析。结果6574例次地高辛血药浓度测定值在治疗浓度0．5—2．0μ·L^-1内的她676例次，占71．1％；低于治疗浓度范围下限（〈0．5μ·L^-1）的共1106次，占16．8％；高于治疗浓度上限（〉2．0μ·L^-1）的共792例次，占12．1％。性别对地高辛血药浓度无显著影响。随年龄增大，地高辛血药浓度呈增高的趋势。结论通过监测地高辛血药浓度说明本院应用地高辛基本合理。对高龄患者应适当减少地高辛剂量。

A/M To analyze the monitoring results of serum concentrations of digoxin from 1988 to 2003 in this hospital. METHODS The serum concentrations of digoxin were measured by fluorescence polarization immunoassay. The serum concentrations of digoxin in 6 574 samples from 3 884 patients were compared and analyzed. RESULTS Among 6 574 samples, the serum concentrations of digoxin in the therapeutic window were 71.1%, 〈 0.5μg. L-^1were 16.8% and 〉 2.0 μg. L^- 1 were 12.1%. The serum concentration of digoxin had a tendency of increase with aging. CONCLUSION It is necessary to routine monitoring serum concentration of digoxin. It can offer the external basis for reasonable usage of the drug in clinic.