清热毓麟汤治疗男性附性腺炎不育的临床观察

Clincal Observation of Qingre Yulin Decoction in Treatment of Male Infertility Caused by Accessory Gland Infection

目的用随机对照试验的方法研究中药复方清热毓麟汤对男性附性腺炎不育的作用。方法60例附性腺炎不育患者随机分为治疗组与对照组(各30例),治疗组采用复方清热毓麟汤随症加减治疗,对照组采用抗生素联合维生素E治疗,疗程3个月,随访6个月,观察6个月妊娠率、精液常规、前列腺按出液常规等指标。结果治疗组治愈8例(26·7%),显效13例(43·3%),有效5例(16·7%),总有效率86·7%。对照组治愈2例(6·7%),显效9例(30·0%),有效12例(40·0%),总有效率76·7%。治疗组治愈率与总有效率均明显高于对照组。合并附性腺炎的不育患者精液质量明显下降,其精子密度、活率及活动力均降低,在治疗后,两组均有改善。但治疗组各项指标改善程度明显均优于西药组。结论合并附性腺炎的不育患者主要表现为少精、弱精,但并非所有附性腺炎均可能引起精液质量下降。清热毓麟汤能全面改善附性腺炎不育患者精液质量,对精子活力的改善尤其明显,可以显著提高患者配偶妊娠率。

Objective To study the effect of Qingre Yulin Decoction （QYD） on male infertility caused by accessory gland infection （AGI） with randomized controlled trial （RCT）. Methods Sixty infertility outpatients were equally divided into two groups randomly, the QYD group treated with modified QYD and the control group with antibiotic plus vitamin E, both for 3 months with another 6 months＇ follow-up. Pregnant rates, routine test of sperm and expressed prostatic secretion （EPS） were determined. Results The healed rate was 26.7 % （8 cases）, the markedly effective rate was 43.3 % （13 cases）, the effective rate was 16.7 % （5 cases）, and the total effective rate was 86.7% in the QYD group, while in the control group it was 6.7% （2）, 30.0% （9）, 40.0% （12） and 76.7% respectively, showing higher healed rate and total effective rate in the former than those in the latter. Sperm quality of infertility patients with AGI decreased obviously, manifesting short ened average liquefaction time, reduced concentration, survival rate and vitality of sperm. These abnormal changes were improved after treatment in both groups, and the efficacy was better in the QYD group than that in the control group. Conclusion Infertility patients with AGI were manifested as oligospermatism and asthenospermia, which may not be the definite outcome of AGI. QYD is able to improve sperm quality, especially sperm vitality in infertility patients with AGI and therefore increase pregnant rate of their wives.