胸痹程度与冠脉病变程度关系初探

Relationship between Pathological Changes of Coronary Artery and Severity of Xiongbi Syndrome

目的评价《中药新药治疗胸痹(冠心病心绞痛)的临床研究指导原则》(简称《原则》)胸痹程度与冠脉造影(coronary angiography,CAG)结果的相关性。方法207例患者参照《原则》胸痹轻重分级,常规做心电图检查,并按Judkins法进行冠脉造影检查,将结果与《原则》标准进行对比。结果冠脉造影结果与心电图关系显示,冠心病1支及2支病变组心电图异常率较冠脉正常组显著增加(P<0.05),但多支病变组反而与冠脉正常组差异无显著性;冠脉正常组胸痹程度与各冠心病亚组比较差异均有显著性(P<0.01),但各冠心病亚组间比较差异无显著性;多支病变组反而以轻度胸痹比例最高(37.0%),中度、较重度及重度所占比例依次下降。结论胸痹程度和冠心病严重程度往往不成正比。

Objective To study the relationship between the outcome of coronary angiography （CAG） and the severity of Xiongbi syndrome diagnosed according to ＂Guiding principle for clinical study on new traditional Chinese medicine in treating Xiongbi （angina pectoris）＂ （abbreviated as the principle）. Methods Severity of Xiongbi syndrome in 207 patients were graded according to the principle and they were examined with CAG by Judkins methods, The relationship between the outcome of CAG and severity of Xiongbi syndrome was analyzed. Results Abnormal rate of ECG was markedly higher in patients with lesion involving 1 or 2 branches of coronary artery than that in patients without coronary artery lesion （P 〈 0.05）, while no significant difference was found in that between patients with multiple-branches lesions and those without lesion. Comparison of Xiongbi syndrome severity showed that there was remarkable difference between patients with normal coronary artery and those with lesions involving different branches （P〈0.01）, but no difference among patients with 1 or 2 branches and those with multiple-branches lesions; on the contrary, mild Xiongbi syndrome took up the highest rate （37%） in patients with multiple-branches lesions, and the rate was lower along with higher severity. Conclusion There was no positive relationship between severity of Xiongbi syndrome and that of coronary artery disease.