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三叶因子基因表达调控相关因子 被引量：3

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摘要 三叶因子在黏膜修复与重建及肿瘤的发生、发展过程中发挥了重要的作用,对其结构与功能及基因表达调控的研究一直是近20余年来黏膜保护及肿瘤研究领域的热点．目前的研究发现,许多转录因子如C／EBPβ、GATA家族、NF-κB等,调节蛋白质如雌激素、EGF及TGFα等,及其他化学物质如NSAIDs、TPA、硫氨素等均参与了三叶因子基因的表达调控过程．通过调节这些相关因子,我们可以充分发挥三叶因子生物学作用中的有利方面,避免其不利方面,为临床应用创造条件．
作者 卢雅丕 任建林
机构地区 福建医科大学 厦门大学附属中山医院消化内科
出处 《世界华人消化杂志》 CAS 北大核心 2006年第30期2907-2912,共6页 World Chinese Journal of Digestology
关键词 三叶因子 基因表达调控
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献43

  • 1卢雅丕,任建林.三叶因子家族研究进展[J].世界华人消化杂志,2003,11(12):2019-2021. 被引量：10
  • 2Masiakowski P,Breathnach R,Bloch J,Gannon F,Krust A,Chambon P.Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line.Nucleic Acids Res 1982; 10:7895-7903
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  • 7Taupin D,Wu DC,Jeon WK,Devaney K,Wang TC,Podolsky DK.The trefoil gene family are coordinately expressed immediate-early genes:EGF receptor-and MAP kinase-dependent interregulation.J Clin Invest 1999; 103:R31-38
  • 8Barkhem T,Haldosen LA,Gustafsson JA,Nilsson S.pS2 Gene expression in HepG2 cells:complex regulation through crosstalk between the estrogen receptor alpha,an estrogen-responsive element,and the activator protein 1 response element.Mol Pharmacol 2002; 61:1273-1283
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二级参考文献44

  • 1Newton JL, Allen A, Westley BR, May FE. The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. Gut 2000;46:312-320.
  • 2Babyatsky MW, deBeaurnont M, Thim L, Podolsky DK.Oral trefoil peptides protect against ethanol and indomethacin-induced gastric injury in rats. Gastroenterology 1996;110:489-497.
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  • 6Dignass A, Lynch-Devaney K, Kindon H, Thim L, Podolsky DK. Trefoil peptides promote epithelial migration through a transforming growth factor-~ independent pathway. J Clin Invest 1994;94:376-383.
  • 7Masiakowski P, Breathnach R, Bloch J, Gannon F, Krust A, Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line.Nucleic Acids Res 1982;10:7895-903.
  • 8Ribieras S, Tomasetto C, Rio MC. The pS2/TFF1 trefoil factor,from basic research to clinical applications. Biochim Biophy Acta 1998;1378:F61-77.
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  • 10Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A,LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 1996;274:259-262.

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世界华人消化杂志
2006年 第30期

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