CTLA-4Ig对大鼠实验性自身免疫性脑脊髓炎的BAEP、SEP的影响

Effect of CTLA-4Ig on BAEP and SEP in rats of experimental autoimmune encephalomyelitis

目的探索CTLA-4Ig转基因治疗实验性自身免疫性脑脊髓炎(experimentalautoimmuneencephalomyelitis,EAE)的疗效和安全性。方法用AdCTLA-4Ig注射到Wistar大鼠EAE模型侧脑室内,观察临床发病情况和电生理改变,以判断其疗效。结果EAE大鼠侧脑室注射AdCTLA-4Ig后,大鼠EAE发病时间延迟,发病率显著下降。且脑干听觉诱发电位和体感诱发电位反映的中枢传导功能显著改善。结论CTLA-4Ig对EAE有明显疗效。

Objective To explore the curative effect and safety of CTLA-4Ig transgene for experimental autoimmune encephalomyelitis （EAE）. Methods The adenovirus loaded CTLA-4Ig was injected into Wistar rat EAE models through the lateral cerebral ventricle. The clinical symptomatic and electrophysiological changes were observed to judge the efficiency of CTLA-4Ig. Results After injection of AdCTLA-4Ig into the lateral cerebral ventricle of Wistar rat EAE models, the time of EAE onset was delayed and the incidence rate was significantly reduced. And the transductive function tested by brain-stem auditory evoked potential （BAEP） and somatosensory evoked potential （SEP） was obviously improved. Conclusion CTLA-4Ig is effective in managing EAE.