多灶性运动神经病的临床特征及治疗

Clinical features and treatment of multifocal motor neuropathy

目的:分析多灶性运动神经病(MMN)的临床特征及治疗方法。方法:回顾性分析24例多灶性运动神经病患者的临床资料。结果:24例MMN表现为进行性、非对称性肢体运动无力,以远端为重,伴或不伴感觉障碍。部分患者抗-GM1抗体滴度升高。10例应用激素治疗,8例无效;20例应用免疫球蛋白(IVIg)治疗,15例有效。结论:MMN是一种以运动神经受累为主的不对称性周围神经病,临床症状和体征是诊断MMN的基础,免疫学检查发现抗-GM1抗体滴度升高支持诊断,但与临床症状和体征并非完全相关,免疫球蛋白(IVIg)治疗有效。

Objective： To investigate the clinical characteristics and treatment of mulfifocal motor neuropathy. Methods： Retrospective ananlysis was performed in 24 patients suffering from multifocal motor neuropathy. Results： 24 cases showed progressive, distal, asymmetric limb weakness, minimal or no sensory impairment. Some cases had an increase dose of anti-GM1. 8 cases showed respond to steroids, 15 cases improved with high dose intravenous immunoglobulin therapy. Conclusions： Mulfifocal motor neuropathy is asymmetric peripheral nerve disorder mostly affecting motor but not sensory nerves, the clinical features are important and the increase of anti-GM1 also helping in the diagnosis of this disease. Most MMN patients improve with high dose intravenous immunoglobulin therapy.