急性缺血性脑血管病患者肺炎衣原体感染与血清C反应蛋白的关系

Association between chlamydia pneumoniae and serum c-reactive protein levels in ischemic cerebrovascular disease

目的:探讨肺炎衣原体感染在急性缺血性脑血管病炎症反应中的作用。方法:检测30例急性缺血性脑血管病患者和30例正常对照者血清中肺炎衣原体特异性抗体IgG和IgM,以及血清C反应蛋白水平。结果:缺血性脑血管病患者血清C反应蛋白水平高于对照者(P<0.01)。血清肺炎衣原体IgG抗体阳性脑血管病患者血清C反应蛋白水平(0.57±0.56mg/dl)高于IgG抗体阴性脑血管病患者(0.42±0.21mg/dl)(P>0.05)。血清肺炎衣原体IgM抗体阳性脑血管病患者血清C反应蛋白水平(0.67±0.73mg/dl)高于IgM抗体阴性脑血管病患者(0.47±0.35mg/dl)(P>0.05)。结论:肺炎衣原体急性和慢性感染均参与急性缺血性脑血管病的炎症反应过程,并与其它卒中因素共同引起血清C反应蛋白水平升高。

Objective： This study was conducted to evaluate a possible role of infection with chlamydia pneumoniae for inflammation in acute ischemic cerebrovascular disease. Mehods： Specific antibodies to chlamydia pneumoniae （IgG and IgM） and c-reactive protein levels were measured in both ischemic cerebrovascular disease group（n=30） and the control group（n=30）. Results：Serum c-reactive protein levels were higher in patiens with acute ischemic cerebrovascular disease than in controls（P〈0.01）. Serum chlamydia pneumoniae IgG positive patients had an elevated c-reactive protein levels （0.57±0. 56 mg/dl）, relative to IgG negtive patients（0.42±0.21 mg/dl） （P〉0.05）. Serum chlamydia pneumoniae IgM positive patients had an elevated c-reactive protein levels（0.67±0.73 mg/dl）, compared with IgM negtive patients （0.47±0.35 mg/dl）（P〉0.05）. Conclusion：Acute and chronic infection with chlamydia pneumoniae , which both play a role in inflammation of acute ischemic cerebrovascular disease, increase levels of serum c-reactive protein complicated with other stroke factors.