肾大部切除、高盐摄食对SD大鼠脑心房钠尿肽的影响

EFFECTS OF SUBTOTAL NEPHRECTOMY AND HIGH SALT INTAKE ON ATRIAL NATRIURETIC PEPTIDE IN THE BRAINS OF RATS

为探讨脑内心房钠尿肽（ＡＮＰ）的作用，本工作采用ＳＤ大鼠，用放射免疫方法测定３／４肾大部切除与高盐摄食后脑内ＡＮＰ的含量。结果表明，对照组大鼠脑内ＡＮＰ分布广泛。３／４肾切除大鼠每日饮水量，尿量均比对照组高（Ｐ＜０．０５），尿钠浓度低于对照组时，脑内ＡＮＰ含量尽管略有增加，但１０个核团（下丘脑室周核、弓状核、室旁核、视前室周核、中缝背核、尾壳核、杏仁核、脑桥背侧部、蓝斑和大脑皮质）ＡＮＰ含量和对照组无明显差别（Ｐ＞０．０５）。高盐摄食组每日饮水量和尿量均比对照组高，且尿钠浓度高于对照组，同时下丘脑室周核和弓状核ＡＮＰ含量比对照组高（Ｐ＜０．０５）。上述结果提示，大脑第三脑室前腹侧区（ＡＶ３Ｖ区）的ＡＮＰ可能在水盐调节上发挥重要作用。

In order to explore the role of brain atrial natriuretic peptide (ANP) in regulatingwater and electrolytes, the changes of the ANP content of various brain areas in the sterins of high salt intake and in 3/4 nephrectomy rats. In control group, a wide distribunon of ANP was observed in different areas of the brain. The amount of daily water intake and urine were larger, and urine sodium concentration was lower in the 3/ 4nephrectomy group than those in the control group (P<0. 05). In the ten nuclei wehave studied, ANP content was not significantly different from that of the control (P>0. 05). In the high salt group, water intake, urine volume and urine sodium conceniration were significantly higher than those in the control. In this group, brain ANP increased in the periventricular nuclues (PVN) and arcute nucleus (Arc) (P<0. 05).The results indicate that ANP in anteroventral region of the third ventricle (AV3V)might play important role in the regulation of water and electolytes.