血管紧张素Ⅱ对肾上腺糖皮质激素分泌的影响

EFFECT OF ANGIOTENSIN II ON THE ADRENAL GLUCOCORTICOIDS SECRETION

本工作观察了血管紧张素Ⅱ（ＡＤ）对豚鼠和狗的肾上腺组织皮质醇分泌量的影响。结果表明：当ＡⅡ浓度≥１０－９ｍｏｌ／Ｌ时孵育液中皮质醇含量显著增加（Ｐ＜０．０１），并且具有较明显的量效关系和时效关系。ＡⅡ以及促肾上腺皮质激素（ＡＣＴＨ）与肾上腺组织或细胞一同孵育时，皮质醇的分泌量明显高于ＡⅡ和ＡＣＴＨ单独存在时的分泌量（Ｐ＜０．０５）。孵育液内游离钙减少时ＡⅡ促皮质醇分泌的作用有所降低（Ｐ＜０．０５）。以上结果提示：（１）高浓度ＡⅡ对肾上腺糖皮质激素具有直接的调节作用：（２）ＡⅡ和ＡＣＴＨ在促进皮质醇的分泌方面具有协同效应；（３）Ｃａ２＋可能参于ＡⅡ促皮质醇分泌机制。

The effect of angiotensin Ⅱon adrenal cortisol secretion was studied using incubated adrenal tissues or cells preparation of guinea pig and dog. The results showed that:the cortisol secretion in guinea pigs was increased by the addition of angiotensin Ⅱinboth dose-dependent and time-dependent manner at concentration≥10-9 mol/L (P<0. 01 ). When ACTH was further added to the angiotensin primed preparation, the output of cortisol was further increased. Deprivation of free calcium largely suppressed theproduction of cortisol induced by angiotensin Ⅱ (P< 0. 05). These resuls suggestedthat angiotensin Ⅱ exerts a direct effect on the secretion of adrenal cortisol, which required the presence of Ca2+ and is promoted by ACTH.