摘要
简单介绍了高速逆流色谱(HSCCC)技术及其在药物分离分析中的应用。通过参阅国内外的文献报道,综述了 HSCCC的仪器类型、特点、溶剂系统、技术发展及近年来在分离分析天然产物、蛋白质、抗生素、手性化合物等领域的研究和应用进展。结果表明,HSCCC 适用于药物有效成分的定性分析与分离,与其他色谱技术联用有望用于中药定量分析。HSCCC 技术在药物研发中有广阔应用前景。
High -speed counter current chromatography （HSCCC） technology and application in the separation and analysis of pharmaceuticals werebriefly introduced. This paper reviews recent development of HSCCC technology and applications of HSCCC in the separations and analysis of natural products, proteins, antibiotics, chiral compounds etc. HSCCC was applied for separation of many compounds and may be used for qualitative and quantitative analysis when coupled with HPLC, MS, NMR etc. HSCCC is a new technology which has wide application in the research and development of pharmaceuticals.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2006年第10期1516-1520,共5页
Chinese Journal of Pharmaceutical Analysis
关键词
高速逆流色谱
药物
分离
分析
HSCCC
pharmaceuticals
separation
analysis
