糖尿病并发下肢血管病变的发病机理及治疗进展

Pathogenesy and Therapeutic Prospect of Diabetes Mellitus Accompanied Lower Limb Vascular Lesion

目的介绍糖尿病合并下肢血管病变的发病机理及治疗进展。方法复习近几年的相关文献,进行综述。结果糖尿病为周围动脉病变的主要危险因素之一,糖尿病血管病变包括大血管病变和微血管病变两种,动脉硬化和微循环的血流减少是下肢缺血的重要因素。下肢的缺血性病变是糖尿病的常见并发症,内科治疗及外科治疗均可改善其症状。结论外科治疗是治疗糖尿病合并下肢血管病变的有效方法。

Objective To investigate pathogenesy and therapeutic prospect of diabetes mellitus accompanied lower limb vascular lesion. Methods Relevant literatures of recent years were reviewed. Results Diabetes mellitus is one of the main risk factor causing peripheral artery disease. The site of vascular lesion often occur in major blood vessel and micrangium. The arterial sclerosis and decreased blood supply in microcirculation are important factors of lower limb ischemia. Lower limb ischemia in patients with diabetes mellitus is a common complication. Medical treatment and surgical treatment are the methods to improve symptoms of the complication. Conclusion Surgical therapy is an effective method for the treatment of diabetes mellitus accompanied lower limb vascular lesion.