阿托伐他汀对高血压合并高脂血症患者内皮功能的影响

Effect of Atorvastatin on Endothelium-dependent Vasodilatation Function in Patients with Essential Hypertension Complicated by Hyperlipidemia

目的:探讨高血压合并高脂血症患者应用阿托伐他汀治疗后对血管内皮舒张功能的影响。方法:168例高血压患者随机分成阿托伐他汀治疗组(观察组)84例及常规治疗组(对照组)82例,比较治疗12周前后应用超声检测肱动脉流量介导性扩张的血管内皮舒张功能及血脂、C反应蛋白(CRP)的变化。结果:观察组和对照组治疗前与治疗12周后比较,血管内皮舒张功能均有显著改善(P<0.01和P<0.05);治疗后两组间比较,血脂、血管内皮舒张功能及CRP水平有显著差异(P<0.05)。结论:高血压合并高脂血症患者应用阿托伐他汀治疗12周后除改善血脂情况外,可进一步改善内皮依赖性血管舒张功能及减轻炎症反应。

Objective： To investigate the effect of atorvastatin on endothelium-dependent vasodilatation function in patients with essential hypertension （EH） complicated by hyperlipidemia. Methods： A total of 168 patients with EH complicated by hyperlipidemia were divided randomly into conventional therapeutic group （control） and atorvastatin treated group. The levels of blood lipid and C-reaction protein （CRP） were measured before and twelve weeks after treatment. Vascular endothelial function was assessed in the brachial artery by high-resolution ultrasound technique in form of flow-mediated dilatation during reactive hyperemia and after sublingual glyceryl trinitrate. Results： Flow-mediated dilatation parameters and the levels of blood lipid and CRP were obviously improved compared with those before treatment in conventional treated group and atorvastatin therapeutic group （P〈0.05 and P〈0.01）. After 12 weeks＇ atorvastatin therapy, the comparison of the results between the two groups showed significant difference （P 〈 0. 05）. Conclusion： Based on the conventional therapy, atorvastatin could further improve vascular endothelial function and resist inflammation of the arteriosclerosis in patients with EH complicated by hyperlipidemia.