单纯疱疹病毒胸苷激酶基因转染对T细胞活化和亚群分布的影响
摘要
为了隆低造血干细胞移植患者移植物抗宿主病（GVHD）的发生，人们试图在输注的淋巴细胞中转染一种自杀基因，这种外源基因使输注的T细胞对特殊药物具有敏感性，设置了一种特定“开关”。当严重的CVHD发生时，应用特定药物特异性杀伤T细胞，达到防治GVHD的目的。为此我们构建了含单纯疱疹病毒胸苷激酶基因（HSV-ik）的pBabe-puro逆转录病毒载体。
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2006年第11期779-780,共2页
Chinese Journal of Hematology
基金
浙江省科技厅国际合作项目(2003C34007)
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