干燥羊膜在青光眼滤过术中的临床应用研究

A randomized control clinical trial of glaucoma filtering surgery with amniotic membrane

目的探讨干燥羊膜在青光眼滤过术中应用的有效、安全性。方法在小梁切除术中移植国产干燥羊膜治疗青光眼22例（26眼），术后随访6～14个月，观察术后视力、滤过泡、前房深度、眼压及术后并发症等情况。结果随访期间眼压由术前43．13±7．82mmHg降至术后18．36±4．20mmHg，P〈0．001。手术总成功率为92．3％，保持功能性滤过泡23眼；术后视力提高2行以上者为18眼（69．2％），并发症主要包括浅前房（3眼）和低眼压（6眼）。结论干燥羊膜在青光眼滤过术中的应用可减少滤过道癍痕的形成，提高手术的成功率，是治疗青光眼安全有效的方法之一。

Objective： To study the effect and sccurity of amniotic membrane transplantation and trabeculectomy. Methods ： Preserved amniotic membrane transplantation and trabeculectomy was performed on 22 cases （ 26 eyes ） of glaucoma, All the cases were followed - up for 6 - 14 months. The visual acuity, filtering bleb, anterior chamber depth, IOP, and the complications of operation were studied. Results： The IOP was lowered （P 〈 0. 001 ） from 43. 13 ± 7.82mmHg preoperatively to 18. 36 ± 4.20 mmHg postoperatively. After operation, 23 eyes maintained functional filtering bleb, 18 eyes（69. 2% ） had improved visual acuity. The comphcations included shallow anterior chamber（3eyes） and early postoperative hypotony（6eyes ）. Conclusions： Aamniotic membrane transplantation and trabeculectomy for glaucoma can effectively inhibit the scar for marion, lower down the IOP to a target level, increase the success rate considerably. The method is safe and effective in the management of glaucoma.