色素上皮衍生因子与糖尿病视网膜病变

Pigment epithelium-derived factor and diabetic retinopathy

色素上皮衍生因子(PEDF)来源于人视网膜色素上皮细胞,是眼内有效的血管生成抑制剂,对保持正常眼组织透明无血管的状态有重要作用。PEDF能对抗多种促血管生成因子,有针对性地抑制病理性血管生成,延缓糖尿病视网膜病变的进展,发挥保护作用。同时,PEDF在眼部浓度降低可增加糖尿病视网膜病变的危险。其作用机制仍在探索中。外源性应用PEDF及进行基因治疗对眼部血管增生性疾病具有显著疗效。因此,深入研究可能会发现PEDF治疗临床血管增生性疾病更广泛的作用。

Pigment epithelium-derived factor（PEDF） secreted from human retinal epithelium cells is a potent angiogenic inhibitor in the mammalian eyes. By excluding aberrant blood vessels from ocular tissues, PEDF plays an important role to keep normal mammalian eyes with visual acuity. Angiogenesis in the retina underlies the pathology of diabetic retinopathy （DR）. PEDF inhibits angiogenic inducers and prevents pathological vascular growth to postpone the pathogenesis of DR. Whereas the lower level of it may be related to the angiogenesis in DR. Its mechanism of action is still in exploration. Recent studies have shown that the curative effect of exogenous PEDF and gene therapies is direct and significant. PEDF may be a useful therapeutic agent for angiogenic disease. Further study of PEDF function may provide a new idea for angiogenic disease in clinic.