市售商品补钙制剂的补钙效果观察

Effect of Fortified Calcium Products on Calcium Status in Rats

本文以大鼠为模型，研究不同化学形式钙以及市售数种钙剂的补钙效果。１．不同化学形式钙的补钙效果：选用三周龄断乳Ｗｉｓｔａｒ大鼠５６只，雌雄各半，喂饲３周缺钙饲料后，按体重随机把大鼠分成４组，即缺钙饲料、补充碳酸钙、活性钙或乳酸钙饲料（３０００ｍｇＣａ／ｋｇ），实验期为１２周。２．市售补钙制剂的补钙效果：选用动物及实验期同实验１，动物数为８４只，按体重随机把大鼠分成７组，即缺钙饲料组，其它６组为补充碳酸钙、钙尔奇－Ｄ、盖天力、活性钙、壮骨宝、巨人补钙饲料（３０００ｍｇＣａ／ｋｇ）。补钙各组大鼠终体重和身长均非常显著高于对照组。补充不同化学形式钙或商品钙制剂组的血浆、红细胞和肝脏中钙含量均显著高于缺钙对照组，补钙各组间无显著差异。多数钙制剂对雄性肾脏钙存留的影响不显著，只有盖天力显著增加雄性肾脏钙存留；补钙对雌性肾脏钙存留的影响非常显著。补充的三种化学形式钙和商品钙剂均显著增加骨矿物质含量，但是碳酸钙和乳酸钙的效果优于活性钙，巨人补钙和活性钙的效果似不如其它钙制剂。按效果价格比，目前碳酸钙仍是最好的钙源。

Effects of different chemical forms of calcium(Ca) and fortified Ca products on Ca status were studied in rats. Experiment I,different chemical forms of Ca. Fifty-six three weeks weaning rats with half male and female were fed with Ca-deficient diet for three weeks,then the rats were randomly divided into four groups(Ca-deficient,CaCO3, active Ca, and lactate Ca groups) ,the added Ca level was 3,000mg/kg of diet. The rats were fed their diets for 12 weeks,Experiment Ⅱ,fortified Ca products. The rat feeding,experimental period and Ca levels were the same as experiment I. Eighty-four rats were divided into seven groups fed with Ca-deficient diet or the diets supplemented with Ca from CaCO3,caltrate-D,Gai-tain-Li, active Ca, Zhuang-gu-bao, and Ju-ren Ca.The results showed that the final body weight and length in the supplemented Ca groups were significantly higher than that of control group. Ca contents in plasma,RBCs and liver of supplemented Ca rats were significantly higher than that of control group,but there was no difference among the supplemented groups. Most of fortified Ca products had no obvious effect on Ca retention in male kidneys except Gai-tian-Li, however,they could significantly enhance Ca retention in female kidneys. The addition of Ca can increase bone mineral content (BMC) in rat femur,and CaCO3 and lactate Ca were superior to the active Ca,for fortified Ca products Ju-ren Ca and active Ca products were not so effieiency as the other fortified Ca products for increasing BMC.