柯萨奇病毒感染与高血压关系的血清学调查

Serum epidemiological study on relationship between Coxsackie′s virus infection and essential hypertension

目的 探讨柯萨奇病毒感染与高血压关系以及在高血脂情况下柯萨奇病毒感染与高血压的关系。方法 对1430例30岁及以上蒙古族农牧民组成的随机样本进行横断面研究，进行血压测量、危险因素调查及血脂和柯萨奇病毒IgG抗体的检测。用SAS8．0软件进行统计分析。采用Logistic回归分析。使用调整后的OR值及95％CI评价各指标对高血压的危险性。结果 30岁及以上人口的高血压患病率为33．7％，高血压组的柯萨奇病毒感染率（58．6％）与血压正常组（59．5％）相比，差异无统计学意义（P=0．401）。经Logistic回归分析，柯萨奇病毒感染者患高血压的危险性（OR）为1．1（0．864～1．4000），P=0．4394。在血脂正常组，柯萨奇病毒感染者患高血压的危险性（OR）为1．078（0．848～1．369），P=0．5412。在高血脂组，柯萨奇病毒感染者患高血压的危险性（OR）为0．879（0．552～1．398），P=0．5848。结论 在血脂正常或异常情况下，柯萨奇病毒感染与高血压的发生无关联。

Objective To explore the relationship between Coxsackie＇s virus in fection and hypertension, and relationship between Coxsackie＇s virus infection and hypertension in the persons with hyperlipidaemia. Methods A random sample of 1 430 Mongolian people≥30 years old was recruited as subjects by using cross-sectional survey. Blood pressure, levels of IgG antibody for Coxsackie＇s virus, blood lipid and cardiovascular risk factors were measured among participants. SAS for Windows 8.0 was used to analyze the data in this study, and Logistic regression analysis was conducted and adjusted OR was used to evaluate the risk of every factor for hypertension. Results Of 1 430 participants, there were 488 hypertensives and 942 normotensives, prevalence was 34.1%. Compared with infection rate of Coxsackie＇s virus（59.5 % ）in normotensives, prevelence of hypertensives（58.6 % ）wasn＇t significant higher than that in normotensives, P = 0.401. By logistic regression analysis, the risk（ OR ）of Coxsackie＇s virus infection for hypertension was 1.1 （0. 864- 1. 400 0）in ortholiposis group, P = 0. 439 4 and 0. 879（0.552-1.398）in hyperlipidaemia group, P = 0.584 8. Conclusion Coxsackie＇s virus infection isn＇t a risk factor for hypertension whether with or without hyperlipemia condition.