芝麻素对肾性高血压大鼠重要脏器中NO含量的影响

Effects of sesamin on nitric oxide contents in vital organs of renal hypertensive rats

目的:观察芝麻素对肾性高血压大鼠(RHR)靶器官脏器系数和NO含量的变化。方法:复制两肾一夹型(2KIC)肾性高血压大鼠模型,将造模成功的RHR随机分为5组,每组7只,给药6周后,计算大鼠心、肝、脑、肾靶器官脏器系数并用硝酸还原酶法测定各器官一氧化氮(NO)含量。结果:芝麻素[100 mg/(kg.d)]可明显降低心脏和肾脏系数及升高心、肝和肾中NO含量。结论:芝麻素对肾性高血压大鼠靶器官具有一定的保护作用。

Objective：To investigate the effects of sesarnin on organ relative weight and the change of nitric oxide in vital organs of renal hypertensive rats（RHRs）, Methods： RHRs induced by 2KIC were divided into 5 groups randomly with 7 rats in each. After six weeks of treatment, proportion of target organs and concentration of nitric oxide（NO） were measured in heart tissues, liver, brain and kidney, respectively. Results： Sesamin （100 mg/kg/d, P. O. ） could depress the relative weight of heart and kidney or increase the contents of NO in heart, liver and kidney, Conclusion ： It suggests that sessmin can protect target organs in renal hypertensive rats.