阻黄联合肝切除术残肝储备功能变化及TNF-α和IL-6对其影响

Effects of TNF-α and IL-6 on the survival liver function after hepatectomy in obstructive jaundice rats

目的：观察阻塞性黄疽（间称阻黄）大鼠施行肝切除术后细胞因子TNF-α和IL-6的变化及其对残肝功能影响。方法：采用胆总管结扎的方法制成大鼠胆道梗阻模型。10d后采用肝蒂结扎法切除大鼠左肝叶和中肝叶（约65％-70％）或左肝叶（约30％），同时行胆肠内引流术。术后不同时段检测剩余肝功能及TNF-α和IL-6的变化。结果：阻黄组IL-6值变化明显，IL-6和残肝功能呈V形改变，TNF-α变化不明显。结论：在阻黄患者中行肝切除术，细胞因子级联反应对残肝功能影响较大。

Objective：To observe the alteration of TNF-α, IL-6 and its effects on the survival liver function after hepateetomy with a removal of 30% or 50% in obstructive jaundice rats. Methods： OJ group was undergone through bile duct ligation, Ten days later all rats were undergone hepatectomy by Higgins Anderson method with removal of some 65% -70% of its left liver or middle part of it or 30% of its left liver. A silicon tube was used to bridge between the bile duct and duodenal for draining the bile flow in OJ group. Alteration of TNF-α, IL-6 and its effects on the survival liver function were detected postoperatively. Results ：Compared with control group, the level of IL-6 and the survival liver function showed an alteration of V shape in OJ group, but the level of TNF-α showed a little change. Conclusion ： The damage of the cytokine cascade to the survival liver is beyond evaluation in the surgery for it can produce great effect on such cases.