碳酸锂治疗抗精神病药所致白细胞降低21例疗效观察

Efficacious observation of 21 cases of lithium carbonatein cure low leucocyte amount due to psychotic drugs

目的：了解碳酸锂对抗精神病药所致白细胞降低的疗效。方法：1995年1月-2002年1月住院男性病人服用抗精神病药所致白细胞降低21例，加用碳酸锂0．25g，2次／d，口服或0．5-0．75g／d。每晚口服。结果：治愈16例（76．2％）；显著进步2例（9．5％）；进步1例（4.8％）；无效2例（9．5％）。无效者中1例为合并急性粒细胞性白血病，1例为合并肝炎、肝硬化。结论：碳酸锂对精神药物所致白细胞降低者有良好的疗效，并有显效快、副反应低、用药量低的特点。

Objective：To understant the efficacy of lithium carbonate in cure low leucocyte amount due to psychotic drugs.Methods：21 inpatients with low leucocyte amount due to psychotic drugs was treated with lithium carbonate when the leuco - Cyte amount is lower than norreal, the dosage is between 0.5 - 0.75 per day. Results： The cure rate is 76.2 %, markedprogress rate is 9.5 %, progress rate is 4.8 %, 2 cases no respose to lithium carbonate, make up 9.5 % of the total, one patient is complicated by acute granuiocytic leukemia and the other is accompany with hepatitis and cirrhosis of liver. Conclusion： Lithium carbonate have good efficacy to low leucocyte amount due to psychotic drugs, and it produce an instant effect and lowside effec, the low dosage is used.