氨溴索对慢性阻塞性肺疾病患者气道炎症的影响

The effect of ambroxol against airway inflammation of patients with chronic obstructive pulmonary disease

目的探讨氨溴索对慢性阻塞性肺疾病(COPD)患者气道炎症的影响。方法选择40例COPD急性加重期患者,随机分成氨溴索治疗组和对照组,并选择健康老年人18例作为正常对照组。观察其支气管肺泡灌洗液(BALF)中IL-8及TNF-α的变化。结果氨溴索组和对照组患者BALF中IL-8及TNF-α含量均高于正常组,两组治疗前无显著差异,治疗10天后A组水平较B组下降(P<0.01)。结论氨溴索可以抑制COPD急性加重期患者的气道炎症反应过程。

Objective To investigate the inhibitory effect of ambroxol against airway inflammation of COPD patients. Methods 40 COPD patients in the stage of acute exerbation were randomly divided into two groups, bronchial alveolar lavage （BAL） were performed as usual. The concentrations of IL-8 and TNF-α in bronchial alveolar lavage fluid （BALF） were measured by ELISA. The concentrations of protein in BALF were measured by Coomssie brilliant blue way. The results＂ were compared with that of 18 healthy volunteers. Results Both the level of IL-8 and TNF-α in BALF in patients with COPD were significantly higher than that of the healthy subjects （P〈0.01, respectively）. Both the concentrations of IL-8 and TNF-α in BALF in group A were significantly lower than that in group B （P〈0.01, respectively） after 10 days treatment of ambromol. Conclusions Ambroxol could inhibit the local inflammatory course of COPD patients in the stage of acute exerbation.