抗精神病药物对血清钾的影响

Effect of antipsychotic on serum potassium

目的探讨抗精神病药物对血清钾的影响。方法对2002年1月至2003年10月对首次住我院65例精神分裂症病人定期测血钾。结果低血钾总发生率27.4%,低血钾组病人年龄>正常组病人p<0.01,低血钾高温天气发生较多.氯丙嗪和氯氮平单用药发生率高。结论对服抗精神病药病人要定期,随时复查血清钾,发现异常及早干预。

Objective To explore the effect of antipsychotic on serum potassium. Methods To measure the serum potassium levels periodically of the 65 sehizophrenia patients first sent to our hospital during 2002.1- 2003.10. Results The incidence of hypokalemia is 27.4%. The average age of hypokalemia group is over the normal group （p〈0.01）. Hypokalemia occurs more frequently in hot weather. Patients who take beth clozapine and chlorpromazine suffer from hypokalemia more easily than take either clozapine or ehlorpromazine. Conclusions The levels of serum potassiun of patients treated with antipsychotic should be measured periodically or at any time. Once abnormality occurs, it should be treated timely.