庚酸睾酮男性抗生育作用的临床研究

A Clinical Study on Antifertility of Testosterone Enantbate in Normal Men.

６２名健康男性，自愿接受每周１次２００ｍｇ庚酸睾酮（ＴＥ）肌肉注射的避孕方法研究，４人非医学原因中断试验，其余受试者先后实现无精子，自第１次ＴＥ到全部达到无精子的平均时间为１０８（５８－２３２）天。在此后的连续１２个月共５９２个妇女月避孕效果观察中，有１例怀孕，临床避孕率为９８％，停药后，平均１８８（１３５－２５４）天全部受度者的精子密度恢复到用药关呈高于２０×１０＾６／ｍｌ。在用药期间。

A clinical study was conducted to assess the contraceptive efficacy, safety and reversibility of testosterone enanthate (TE)-induced azoospermia in 62 healthy fertile men. Each subject received 200 mg TE weekly by intramuscular injection. All men became azoopermic in three consecutive semen samples. The mean time to become azoosper- mic was 102 (58 - 232) days. These men entered a 12-months efficacy phase during which continuous TE injections were the only form of contraception. There was 1 pregnancy during 592 months of the efficacy phase (2. 02 conceptions per 100 person-years). There were no serious treatment-related side effect except acne occurring in two men during treatment. The mean time of recovery to normal sperm concentration was 188 (135 - 254) days. It is concluded that TE-induced azoospermia can provide highly effective, sustained, and reversible contraception for men with minimum side-effects.