病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达

Expression of Survivin, P33ING1, and Caspase-3 proteins in pathologic scar tissue

目的检测病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达情况。方法采用免疫组织化学方法检测30例病理性瘢痕组织、10例非病理性瘢痕和20例正常皮肤组织中Survivin、P33ING1、Caspase-3的表达情况。结果病理性瘢痕、非病理性瘢痕和正常皮肤组织中Survivin、P33ING1和Caspase-3的阳性表达率分别为80.0%、50.0%、35.0%,43.3%、70.0%、85.0%和30.0%、80.0%、90.0%;病理性瘢痕组织与非病理性瘢痕和正常皮肤组织比较,3指标差异均有统计学意义(P<0.05)。病理性瘢痕组织中Caspase-3与Survivin(r=-0.400)和P33ING1(r=0.602)表达均具有相关性(P<0.05)。结论Survivin的高表达与Caspase-3和P33ING1的表达下调在病理性瘢痕的形成中可能起协同作用。

Aim： To investigate the expressions of apoptosis-related Survivin, P33ING1, and Caspase-3 in pathologic scar formation. Methods： The expressions of Survivin, P33ING1, and Caspase-3 in 30 cases of pathologic scar, 10 cases of non-pathologic scars, and 20 cases of normal skin tissue were detected using immunohistochemical methods, Results： The positive rates of survivin, P33ING1, and Caspase-3 in pathologic scar, non-pathologic scar, and normal skin tissue were 80.0% ,50.0% ,35.0% ,43, 3% ,70.0% ,85.0% and 30.0% ,80.0% ,90.0% , respectively, Compared with non- pathologic scar and normal skin cases, the expressions of Survivin, P33ING1 , and Caspase-3 had significant difference in pathologic scar cases（P 〈 0.05）. Caspase-3 expression were correlated with Survivin （ r = - 0. 400 ） and P33ING1 （ r - 0.602） in pathologic scar tissue （P 〈 0. 05 ）. Conclusion： The uverexpression of Survivin and down-regulation of Caspase-3 and P33ING1 expressions may play a coordinated role in pathologic scars.