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Wnt/β-Catenin通路:抗癌药物作用的新靶点

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作者 陈劲松 杨杰 梁庆模
机构地区 南华大学附属南华医院
出处 《中国药房》 CAS CSCD 北大核心 2006年第22期1743-1745,共3页 China Pharmacy
关键词 WNT/Β-CATENIN通路 抗癌药物 治疗方法 恶性肿瘤
分类号 R979.1 [医药卫生—药品]
  • 相关文献

参考文献18

  • 1Mikami I,You L,He B,et al.Efficacy of Wnt-1 monoclonal antibody in sarcoma cells[J].BMC Cancer,2005,5(1):53.
  • 2He B,You L,Uematsu K,et al.A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells[J].Neoplasia,2004,6(1):7.
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  • 4Nagayama S,Fukukawa C,Katagiri T,et al.Therapeutic potential of antibodies against FZD 10,a cell-surface protein,for synovial sarcomas[J].Oncogene,2005,24(41):6 201.
  • 5Boon EM,Keller JJ,Wormhoudt TA,et al.Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines[J].Br J Cancer,2004,90(1):224.
  • 6Chang WC,Everley LC,Pfeiffer GR,et al.Sulindac sulfone is most effective in modulating beta-cateninmediated transcription in cells with mutant APC[J].Ann N Y Acad Sci,2005,1 059:41.
  • 7Maier TJ,Janssen A,Schmidt R,et al.Targeting the beta-catenin/ APC pathway:a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells[J].FASEB J,2005,19(10):1 353.
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  • 9朱红霞,张果,王益华,周翠琦,白瑾峰,徐宁志.非甾类抗炎药通过β-catenin/TCF4-survivin通路诱导结肠癌细胞凋亡[J].癌症,2004,23(7):737-741. 被引量：22
  • 10Gao J,Liu X,Rigas B.Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress[J].Proc Natl Acad Sci USA,2005,102(47):17 207.

二级参考文献12

  • 1Hugh TJ,Dillon SA,O' Dowd G,et al.Beta-catenin expression in primary and metastatic colorectal carcinoma [J].Int J Cancer,1999,82,504-511.
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  • 3Van de Wetering M,Sancho E,Verweij C,et al.The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells [J].Cell,2002,111:241-250.
  • 4Li H,Pamukcu R,Thompson WJ.Beta-catenin sigaling:Therapeutic strategies in oncology [J].Cancer Biol Ther 2002,1;621-625.
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  • 6Zhang T,Otevrel T,Gao Z,et al.Evidence that APC regulates survivin expression:A possible mechanism contributing to the stem cell origin of colon cancer [J].Cancer Res,2001,62:8664-8667.
  • 7Kim PJ,Plescia J,Clevers H,et al.Survivin and molecular pathogenesis of colorectal cancer [J].Lancet,2003,362:205-209.
  • 8Ambrosini G,Adida C,Altieri DC.A novel anti-apoptosis gene,survivin,expressed in cancer and lymphoma [J].Nat Med,1997,3:917-921.
  • 9Zhang T,Fields JZ,Ehrlich SM,et al.The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cells [J].J harmacol Exp Ther,2004,308(2):434-437.
  • 10Kawasaki H,Toyoda M,Shinohara H,et al.Expression of survivin correlates with apoptosis,proliferation,and angiogenesis during human colorectal tumorigenesis [J].Cancer,2001,91:2026-2032.

共引文献21

中国药房
2006年 第22期

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