摘要
目的研究美托洛尔治疗慢性充血性心力衰竭(CHF)的临床疗效及安全性。方法60例CHF患者随机分为2组,对照组:采用常规治疗方法(ACEI/ARb、利尿剂、地戈辛);治疗组:在对照组治疗的基础上,加用美托洛尔,治疗15周。治疗前后检查超声心动图,并行6分钟步行试验。结果治疗组显示心功能明显改善(P<0.01),左心室射血分数明显增加(P<0.05),6分钟步行距离明显增加(P<0.01)。结论美托洛尔在常规治疗CHF的基础上,对CHF患者安全有效,可作为CHF的常规治疗。
Objective To discuss clinic efficacy and safety of metoprolol on chronic congestive heart disease （CHF）. Method 60 patients with CHF were divided into two groups： control group which was treated with conventional methods. （ACEI/Arb,diuretie and digoxin） ;therapy group which was added carvedilol with the basic treatment for 15 weeks. All patients were examined by echocardiography at the beginning and end trial and 6 minutes test. Results Heart function of therapy group was significantly improved（ P 〈 0.01 ） and left ventricular ejection fraction （ P 〈 0, 05 ）. The distance of 6 - minute walk test also increased （ P 〈 0, 01 ）. Conclusion Metoprolol is safety and efficacy to CHF with basic treatment.
