缺血性脑卒中患者急性期血清C反应蛋白水平与预后的关系

Relationship Between Serum Level of C-Reactive Protein and Prognosis of Cerebral Infarction

目的探讨急性脑梗死患者血清C反应蛋白(CRP)水平与疾病预后的相关性方法。方法对80例脑梗死患者(脑梗死组)、20例腔隙性脑梗死患者(腔梗组)和40名健康体检者(对照组)血清CRP含量进行测定,计算其异常率并进行比较。按脑卒中患者临床神经功能缺损程度评分(NHISS)标准对患者进行评分。结果脑梗死组CRP含量高于腔梗组,腔梗组高于对照组(均P<0.01);脑梗死组中,CRP异常率高于腔梗组(P<0.05);CRP异常的患者NHISS的评分的改善低于CRP正常组,且CRP异常者预后中无变化和死亡明显高于正常对照者(均P<0.01)。结论CRP水平是临床评价脑梗死严重程度和预后的一个重要的生物学指标。

Objective To investigate the serum level of C - reactive protein （CRP）in patients with cerebral infarction and its effect on prognosis of brain infarction, Methods 113 patients（48 with thrombosis and 43 with lacunar infarction）and 41 healthy persons as control were enrolled in this study. The serum level and abnormal rate of CRP were determined. All the patients were scored by clinic neurological function deficit scale （ NHISS）. Results the serum level of CRP in the patients with thrombosis was higher than that in the patients with lacunar infarction. It was also higher in the patients with lacunar infarction than in normal controls （ all P 〈 0.05 ）. Higher abnormal rate of CRP was found in the patients with thrombosis than in the patients with lacunar infarction （ P 〈 0.05 ）. The group with abnormal serum level of CRP had lower score of NHISS and worse prognosis （all P 〈0.01 ）. Conclusion Serum level of CRP is an important biological market to evaluate the severity prognosis of cerebral infarction.