极低频磁场对大鼠急性和慢性关节炎影响的研究

EFFECTS OF EXTREMELY LOW MAGNETIC FIELD ON ACUTE AND CHRONIC ARTHRITIS OF RATS

目的:探讨极低频磁场对大鼠急性和慢性关节炎模型的影响。方法:大鼠足内皮下注射角叉菜胶建立急性关节炎模型,磁场分别暴露6h和8h,注射弗氏完全佐剂建立慢性关节炎模型,磁场暴露7d,每天6h,观察炎症肿胀和炎性细胞因子的改变情况。结果:急性和慢性关节炎大鼠经过不同时间的磁场暴露后,踝关节和足垫肿胀均有不同程度的减轻,急性模型暴露6h和慢性模型血清和关节液的细胞因子均无改变,急性模型暴露8h血清IL-6,关节浸液IL-6和TNF-α均比对照组降低,其余指标无变化,但是有下降的趋势。结论:极低频磁场对急性和慢性关节炎肿胀有抑制作用,每天暴露8h可以部分抑制细胞因子的产生,但其详细机制还有待于进一步研究。

To investigate the effects of extremely low magnetic field on acute and chronic arthritis of rats. Methods： The acute arthritis animal models were built by the right thenar hypodermic injection of carrageenan. Then they were exposed to magnetic field for 6 hours and 8 hours, respectively. The chronic arthritis animal models were built by the right thenar hypodermic injection of complete freund＇s adjuvant. They were exposed to magnetic field for 7 days and 6 hours each day after the secondary affection appeared 15 days later. The swelling and inflammatory cytokine were observed in both the acute and chronic arthritis models. Results： The anklee and thenar swellings decreased in both the acute and chronic arthritis models after different time exposure. The cytokine of serum and articular lixivium did not change in 6 hours exposed groups of acute arthritis models. The serum IL-6 and articular lixivium IL-6, TNF-α decreased compared with sham groups. Though the rest indexes were unchanged, they had the tendency of decrease. Conclusion： The extremely low magnetic field has the effects of restraining acute and chronic arthritis of rats, and can also partially restrain the cytokines when the rats were exposed for 8 hours. The mechanisms need to be further investigated.