国产加巴喷丁治疗带状疱疹后神经痛的临床疗效及安全性

The effectiveness and safety of domestic Gabapentin in the management of post-herpetic neuralgia

目的：观察国产加巴喷丁（Gabapentin）治疗带状疱疹后神经痛（PHN）的临床疗效及安全性。方法：PHN患者33例，采用双肓、安慰剂对照，随机分为安慰剂组（n=16）和加巴喷丁组（n=17）。采用视觉模拟评分（VAS）评估患者用药前和用药后1、2、4周疼痛程度，同时观察患者的不良反应，并记录治疗前后血、尿常规和肝、肾功能等指标。结果：加巴喷丁组患者口服900～2400mg／d加巴喷丁，与用药前VAS值[（73．00±11．08）mm]相比，用药后4周VAS值[（28．47±9．40）mm]显著下降（P〈0．01），与安慰剂组VAS值[（53．81±7．73）mm]相比显著降低（P〈0．01）。加巴喷丁组除1例患者因严重眩晕退出外，其他患者对药物均表现出良好的顺应性。结论：国产加巴喷丁治疗PHN是有效而安全的。

Objective ： To study the effectiveness and safety of domestic gabapentin in patients with postherpetic neuralgia（PHN）. Methods：Thirty three patients with PHN were double blindly placebo controlled trial and randomly allocated into two groups, group A （placebo ,n = 16） and group B （gabapentin, n = 17）. The quantification of severity of pain was done using visual analogue scale （VAS） at the beginning of the study and after 1 weeks, 2 weeks and 4 weeks. Adverse reactions were also observed. Detailed biochemical investigations, including routine blood and urine examination, liver and renal function tests were done at the beginning and at the end of the study. Results：After 4 weeks treatment with 900 - 2 400 mg/day gabapentin, there was significant reduction in pain [ VAS ： （ 73.00 ± 11.08 ） mm vs （28.47 ± 9.40） mm, P 〈 0.01 ], that in comparison to placebo [ （53.81± 7.73 ） mm, P 〈 0.01 ]. The drug was well tolerated by all patients, except one who developed severe vertigo after 3 days of treatment. Conclusion：Gabapentin provides significant pain relief in patients of PHN, with very little incidence of adverse reactions.