甘精胰岛素与胰岛素泵的基础胰岛素剂量比较

Comparison of insulin dose using glargine insulin and insulin pump

目的:甘精胰岛素和胰岛素泵均能为糖尿病(DM)患者提供基础胰岛素,探讨这两种治疗方法之间的剂量关系,总结甘精胰岛素的临床应用经验。方法:DM患者应用胰岛素泵治疗2周,血糖控制理想后,再改为甘精胰岛素及其他降糖药,血糖平稳后,比较甘精胰岛素与胰岛素泵所用胰岛素剂量,分析其相关性。结果:甘精胰岛素剂量约为胰岛素泵总量的35%及基础量的55%,并与之呈直线正相关,相关系数(r)分别为0.77和0.74,差异具有显著性统计学意义(P<0.001)。结论:甘精胰岛素的起始剂量约为胰岛素泵所用胰岛素总量的35%及基础量的50%,均与甘精胰岛素的起始剂量呈直线正相关。

Objective ：To explore the dose relationship between glargine insulin and insulin pump both used to provide patients with diabetes mellitus with basal insulin requirements. Methods：Patients with diabetes modulated their blood glucose concentration with insulin pump in an ideal level about 2 weeks, then removed insulin pump and used glargine insulin at bedtime and other hypoglycemia agents. The insulin doses were compared between glargine insulin and insulin pump therapy, their relationship were analyzed. Results：The insulin dose with glargine insulin is 35% of the total insulin dose and 50% of the basal insulin dose with insulin pump therapy. The coefficient variation is 0.77 and 0.74 （ P 〈 0. 001 ）. Conclusion ：The first insulin dose with glargine insulin therapy may be 35% of the total insulin dose and 50% of the basal insulin dose with insulin pump treatment.