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microRNA与肿瘤相关性研究进展 被引量：8

Progresses on the study of microRNA and cancer
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摘要 m icroRNA(m iRNA)是真核生物中一类长度约为22个核苷酸、参与基因转录后水平调控的非编码小分子RNA。近年来研究发现,m iRNA除了具有调控细胞增殖、死亡、细胞分化、个体发育等生物学功能以外,与肿瘤的发生也有着密切的关系。该文作者试图从m iRNA的生物学特性、形成、生理功能、作用机制及与肿瘤的关系等方面的研究进展作一综述。 microRNA with 22 nucleotides in length are a growing family of small non -coding RNA that function as post-transcriptional regulators of target genes in eukaryote. Recent study indicates that microRNA are closely related to the oncogenesis additional to its biological function in the regulation of cell proliferation, differentiation and death. This review proposes the progresses on the study of microRNA, including the biological character, biogenesis and function, and its relationship with cancer.
作者 杜莉莉 管晓翔 陈龙邦
机构地区 南京军区南京总医院南京大学医学院临床学院肿瘤科
出处 《医学研究生学报》 CAS 2006年第11期1024-1027,共4页 Journal of Medical Postgraduates
基金 国家自然科学基金资助项目(批准号:30470669)
关键词 MICRORNA 非编码RNA 肿瘤 microRNA Non-coding RNA Cancer
分类号 R730.2 [医药卫生—肿瘤]
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参考文献28

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二级参考文献24

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共引文献12

同被引文献69

  • 1徐锋,高建平,程文.MicroRNA与肿瘤[J].东南国防医药,2008,10(6):436-438. 被引量：6
  • 2李金恒,陈冰.基因芯片及其在突变检测中的应用[J].医学研究生学报,2005,18(1):54-58. 被引量：13
  • 3高杰,杨彤涛,裘秀春,鱼兵,韩建伟,范清宇,马保安.成骨肉瘤细胞SOSP-9607中miRNA的克隆与验证[J].癌症,2007,26(6):561-565. 被引量：16
  • 4马卓娅,汤华,李欣,刘民,吴海东,王晶.MicroRNA在6种肿瘤细胞中的表达差异[J].中国肿瘤生物治疗杂志,2007,14(3):254-258. 被引量：8
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  • 8Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [ J ]. Proc Natl Acad Sci USA, 2006, 103(33): 12481-12486.
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引证文献8

二级引证文献49

医学研究生学报
2006年 第11期

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