高原对大鼠血浆与组织6一Keto一PGF_（1α）和TXB_2含量的影响及丹参

THE EFFECTS OF PLATEAUS ON CONTENT OF TXB_2 AND 6-KETO一PGF_1a IN PLASMA AND TISSUES OF RATS AND PROTECTIVE EFFECTS OF “DANSHEN”(DS)

为观察高原对大鼠血浆与组织６一Ｋｅｔｏ一ＰＧＦ＿（１α）和ＴＸＢ＿２含量的影响及丹参的保护作用。采用３Ｈ一ＴＸＢ＿２及３Ｈ－６一Ｋｅｔｏ一ＰＧＦ＿（１α）药盒及方法。结果：平原大鼠进入海拔４４７５ｍ高原后，其心、肝、脾脏组织及血浆中血栓素Ｂ＿２（ＴＸＢ＿２）含量显著升高（Ｐ＜０．０５）；心脏和血浆中６一酮一前列腺素Ｆ＿（１α）（６一Ｋｅｔｏ一ＰＧＦ＿（１α））含量则显著降低（Ｐ＜０．０１）；各项Ｔ／Ｋ比值均显著增大（Ｐ＜０．０１），丹参合剂能有效地预防高原低氧环境对大鼠的上述影响（Ｐ＜０．０５或Ｐ＜０．０１）。提示该药用于防治而原疾病值得深入研究。

o observe the effects of plateaus on content of TXB_2 and 6-Keto-PGF_(1α) in plasina and tissuesof rats and protective effects of“Danshen”(DS) ,by means of the medicaments and methd of 3H-TXB_2 and 3H一Keto一PGF_(1α), After the rots were transferred to a plateaus area with an elevation of 4475m from a plain area,the content of TXB_2 in heart,liver,spleen and plasma got obviously increased(P<0.05),but the content of 6一Keto一PGF_(1α) in heart and plasma obviously decreased(P<0. 01).A highly xignificant in crease in the ratio of T/K(P<0. 01) has always been observed in all the cases,the mixtura of “Danshen”(DS)can efficiently protect the rats from the plateaus reaction describedabove(P<0. 05 or P<0.01);It will be worth studing if the medicinal herbs may be a goed candi-date for prevention of the mountain sickness.