思密达治疗胆汁返流性胃炎的作用观察

Observatiou of the effect of Smecta on the treatment of bile reflux gastritis

目的：探讨思密达对胆汁返流性胃炎的治疗作用。方法：对经内镜及空腹胃液三羟胆酸测定确诊的３４例胆汁返流性胃炎的海员患者用思密达（Ｓｍｅｃｔａ）治疗２周，检测治疗前、后空腹胃液三羟胆酸含量，又取其中１５例的胃液标本进行了体外思密达和硫糖铝吸附胆酸作用的比较观察。结果：思密达治疗后患者胃液中三羟胆酸含量从１１７．４８±２１．９２μｇ／ｍｌ下降为２４．３２±３．８６μｇ／ｍｌ（Ｐ＜０．０５）。体外实验的胃液标本中加入思密达后，三羟胆酸从１０６．６１±５１．１３μｇ／ｍｌ降至９．００±４．９０μｇ／ｍｌ，与硫糖铝比较作用较明显，差异有显著意义（Ｐ＜０．０５）。结论：思密达是治疗胆汁反流性胃炎的有效药物。

Aim:To explore the therapeutic effect of Smecta(dioctahedral smectite ) on bile reflux gastritis,Methods:Smecta were used in treating bile reflux gastritis for two weeks in 34 sailors.The diagnosis was confirmed by gastroscopy and gastric juice trihydroxycholic acid determination. Determi-nations of the gastric juice trihydroxycholic acid as well as gastroscopy were made both before and after the treatment.Fifteen gastric juice samples of the patients were studied by using the in vitro gastric juice trihydroxycholic acid adsorbent test with Smecta and Sucralfate for comparison. Results:In this group of 34 patients it was found that the gastric juice trihydroxycholic acid was significantly reduced from 117.48±21. 92μg/ml to 24. 32±3.86 μg/ml(P<0. 05).In samples of the in vitro adsorbent test the gastric juice trihydroxycholic acid decreased from 106. 6±51. 13 μg/ml to 9.00±4. 90 μg/ml with Smecta(P<0. 01) and to 79. 09±20. 47 μg/ml with Sucralfate(P>0.05),and so there was significant difference between them(P<0.05). Conclusion:Smecta is an effective drug in treating bile reflux gas-tritis.