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黑色素浓集激素受体与肥胖 被引量：1

Melanin-Concentrating Hormone Receptor and Obesity
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摘要 黒色素浓集激素(melanin-concentratinghormone,MCH)是一种含有19个氨基酸的神经肽,主要存在于下丘脑。它有MCHR1和MCHR2两种G蛋白偶联受体,两种受体的分布及在大脑中的表达基本相似,但MCHR2不存在于啮齿动物中。MCHR1可与多种G蛋白偶联而MCHR2主要与Gq蛋白偶联。MCH与受体结合后将介导不同的信号通路。MCH是机体能量稳态系统中一种关键调节因子,与肥胖发生有关。 Melanin-concentrating hormone （MCH） is a 19-amino acid neuropeptide, which is mainly found in the hypothalamus. MCH has two G-protein coupled receptors （MCHR1 and MCHR2） , and the distribution and expression of MCHR1 and MCHR2 in the brain are essentially same, but MCHR2 does not express in rodents. MCHR1 can couple with several subtypes of G protein while MCHR2 mainly couples with Gq protein. MCH activates several different signal transduction pathways after binding with its receptors. MCH is the key regulator in energy balance system, and it is associated with obesity.
作者 袁成福 宋方洲
机构地区 重庆医科大学生物化学与分子生物学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2006年第6期438-441,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.30671008)~~
关键词 黑色素浓集激素受体 神经肽 信号通路 肥胖 melanin-concentrating hormone receptor neuropeptide signal pathway obesity
分类号 Q45 [生物学—生理学] R3 [医药卫生—基础医学]
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参考文献14

  • 1[1]SAITO Y,NOTHACKERH-P,WANG Z,et al.Molecular characterization of melanin concentrating hormone receptor[J].Nature,1999,400 (6741):265-269.
  • 2[2]MACDONALD D,MURGOLO N,ZHANG R,et al.Molecular characterization of the melanin concentrating hormone/receptor complex:identification of critical residues involved in binding and activation[J].Mol Pharmacol,2000,58(1):217-225.
  • 3[3]KOKKOTOU E G,TRITOS N A,MASTAITIS J W,et al.Melaninconcentrating hormone receptor is a target of leptin action in the mouse brain[J].Endocrinology,2001,142(2):680-686.
  • 4[4]EBERLE A N,MILD G,SCHLUMBERGER S,et al.Expression and characterization of melanin-concentrating hormone receptors on mammalian cell lines[J].Peptides,2004,25 (10):1585-1595.
  • 5[5]FRY D,DAYTON B,BRODJIAN S,et al.Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1)[J].Int J Biochem Cell Biol,2006,38 (8):1290-1299.
  • 6[6]FRANCKE F,WARD R J,JENKINS L,et al.Interaction of neurochondrin with the melanin concentrating hormone-receptor 1 interferes with G protein-coupled signal transduction but not agonistmediated internalization[DB].J Biol Chem,2006 Aug 31,[Epub ahead of print].
  • 7[7]SAITO Y,TETSUKA M,SAITO S,et al.Arginine residue 155 in the second intracellular loop plays a critical role in rat melaninconcentrating hormone receptor 1 activation[J].Endocrinology,2005,146(8):3452-3462.
  • 8[8]LUDWIG D S,TRITOS N A,MASTAITIS J W,et al.Melaninconcentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance[J].J Clin Invest,2001,10(3):379-386.
  • 9[9]BURDYGA G,VARRO A,DIMALINE R,et al.Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones[J].Neuroscience,2006,137(4):1405-1415.
  • 10[10]BJURSELL M,GERDIN A K,PLOJ K,et al.Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin deficient mice without affecting body weight[J].Diabetes,2006,55 (3):725-733.

同被引文献20

  • 1李春蕊,刘文励,孙汉英,周剑峰.瘦素mRNA和瘦素受体mRNA在乳腺癌合并肥胖症患者乳腺癌组织中的表达及其与临床病理的关系[J].中国现代医学杂志,2007,17(13):1569-1571. 被引量：6
  • 2Atkinson R L.Viruses as an etiology of obesity[J].Mayo Clin Proc,2007,82(10):1192-1198.
  • 3Pasarica M,Mashtalir N,McAllister E J,et al.Adipogenic human adenovirus Ad-36 induces commitment,differentiation,0and lipid accumulation in human adipose-derived stem cell[J].Stem Cells,2008,26:969-978.
  • 4Nagashima K,Zabriskie J B,Lyons M J.Virus-induced obesity in mice:association with a hypothalamic lesion[J].J Neuropathol Exp Neurol,1992,51(1):101-109.
  • 5Lyons M,Faust I,Hemmes R,et al.A virally induced obesity syndrome in mice[J].Science,1982,216182-85.
  • 6Bernard A,Fevre M M,Bencsik A,et al.Brain structures selectively targeted by canine distemper virus in a mouse model infection[J].J Neuropathol Exp Neurol.1993,52(5):471-480.
  • 7Bernard A,Fevre-Montange M,Giraudon P,et al.Demonstration of viral proteins and RNA in hypothalamus of mice infected by canine distemper virus[J].C R Acad Sci III,1991,313(12):545-551.
  • 8Vasilakopoulou A,Roux C W.Could a virus contribute to weight gain[J].Int J Obes(Lond),2007,31(9):1350-1356.
  • 9Stricker-Krongrad A,Dimitrov T,Beck B.Central and periph eral deregulation of melanin-concentrating hormone in obese Zucker rats[J].Brain Res Mol Brain Res,2001,92(1-2):43-48.
  • 10Griffond B,Verlaeten O,Belin M F,et al.Specific alteration of the expression of selected hypothalamie neuropeptides during acute and late mouse brain infection using a morbillivirus:relevance to the late-onset obesity[J].Brain Res,2004,1022(1-2):173-181.

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医学分子生物学杂志
2006年 第6期

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