酪氨酸激酶Btk家族的结构和功能

The Structure and Function of Btk Family——A Family of Protein-tyrosine Kinases

Btk(Bruton'styrosinekinase,Bruton酪氨酸蛋白激酶)家族是新近发现的一类非受体酪氨酸蛋白激酶,包括Btk等5个成员。该家族成员同源程度高,包括PH、TH、SH2、SH3B及Src1等5个结构功能域,与PI3(磷脂酰肌醇-3-激酶K)、G-蛋白双受体等结合后发生激活,通过PLCg2(磷脂酶C-g2)、PKCbI(丝氨酸-苏氨酸激酶bI)等下游信号分子,参与对血管生成、细胞增殖和凋亡以及细胞运动的调节。

The Btk family kinases is a recently found subfamily of non-receptor protein-tyrosine kinases （PTKs）. It is one of the new members of non-receptor tyrosine kinases, which includes Btk, Itk, Txk, Etk, and Tec. They are characterized by five structural modules： PH （pleckstrin homology） domain, TH domain, SH3 （ Src homology 3 ） domain, SH2 （ Src homology 2 ） domain and kinase （ Src homology 1, ） domain. Increasing evidence suggests that, like Src-family kinases, Btk family kinases play central but diverse modulatory roles in various cellular processes involving angiogenesis, cell proliferation and apoptosis, and modulation of cell motion, through signaling molecules like PLCg2 and PKCbI, after being activated by PI3K, G-protein Biceptor. The present article reviews the structure and functions of Btk family kinases.