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组蛋白赖氨酸去甲基化与基因调控 被引量：1

Histone Lysine Demethylation and Gene Regulation
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摘要 随着组蛋白赖氨酸去甲基化酶的发现,证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。赖氨酸特异性组蛋白去甲基化酶1(lysinespecificdemethylase1,LSD1)是一个FAD依赖性胺氧化酶,它能够特异性脱去单甲基化和二甲基化H3K4和H3K9位点上的甲基基团。JmjC蛋白JHDM1、JHDM2、JMJD23个亚家族都具有组蛋白赖氨酸去甲基化酶活性。目前证实组蛋白甲基化与去甲基化失平衡与肿瘤发生相关。组蛋白赖氨酸去甲基化酶有可能成为一个新的抗肿瘤治疗靶标。 The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification. LSDI is a FAD-dependent amine oxidase and can specifically demethylate H3K4me2/mel and H3K9me2/mel. JmjC protein, including JHDMI, JHDM2 and JMJD2 subfamily, has been recently reported to have histone lysine demethylase activity. The imbalance of histone methylation has been linked to tumorigenesis. Therefore, histone lysine demethylases may serve as a new target for anti-cancer therapy.
作者 彭正良 曹仁贤 文格波
机构地区 南华大学附属第一医院临床医学研究所
出处 《医学分子生物学杂志》 CAS CSCD 2006年第6期446-449,共4页 Journal of Medical Molecular Biology
关键词 组蛋白赖氨酸 去甲基化酶 赖氨酸特异性组蛋白去甲基化酶1 JmjC蛋白 基因调控 histone lysine demethylase LSDI JmjC protein gene regulation
分类号 Q786 [生物学—分子生物学]
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参考文献21

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同被引文献11

  • 1吴欣爱,孙燕,樊青霞,王留兴,王瑞林.乏氧诱导因子1α在食管鳞癌中的表达及其与化疗疗效的关系[J].中华医学杂志,2007,87(25):1783-1785. 被引量：10
  • 2Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res, 2013, 73: 2936-2942.
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  • 7Sun X, Kanwar JR, Leung E, et al. Gene transfer of antisensc hypoxia inducible factor-1 alpha enhances the therapeutic eficacy of cancer immunotherapy. Gene Thre, 2001, 8:638-645.
  • 8Lee JW,Bae SH,Jeong JW,et al. Hypoxia-inducib/e factor( HIF-1 ) a : Its protein stability and biological functions. Exp Mot Med, 2004, 36:1-12.
  • 9Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia- induciblefactor-lalpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer, 2003, 97: 1573-1581.
  • 10Takahashi R, Tanaka S, Hiyama T, et al. Hypoxia-inducible factor-lalpha expressionand angiogenesis in gastrointestinal tromal tumor of the stomach. Oncol Rep, 2003,10:797-802.

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医学分子生物学杂志
2006年 第6期

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