Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae)

二 neuropeptides 从 synganglia (中央神经系统) 被孤立努力滴答响， Ixodes sinensis。他们的主要序列被建立 asLeu-Val-Val-Tyr “ Pro-Trp-Thr-Lys 和 Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu。由热板生物鉴定， neuropeptide 在由剂量依赖者行为的老鼠的显示的强壮的 antinociceptive 效果， whileneuropeptide b 在孤立的老鼠长带上有一些弛缓的效果。这些 neuropeptides 可能涉及下面调整主人“ s 防御反应。

Two neuropeptides were isolated from synganglia （central nervous system） of the hard tick, Ixodes sinensis. Their primary sequences were established as Leu-Val-Val-Tyr-Pro-Trp-Thr-Lys and Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu. By hot plate bioassay, neuropeptide a displayed strong antinociceptive effect in mice by a dose-dependent behavior, while neuropeptide b had some relaxant effects on the isolated rat strip. These neuropeptides might be involved in down-regulating the host＇s defensive reaction.