摘要
目的观察托吡酯治疗神经痛的临床疗效与安全性。方法将118例神经痛患者随机分为治疗组和对照组各59例。治疗组给予托吡酯25或50 mg,b id,po;对照组给予卡马西平100 mg,b id或tid,po。疼痛缓解后继续服1周后停药。治疗2周后评价其临床疗效。结果治疗组和对照组总有效率分别为93.2%,86.4%(P<0.05);不良反应发生率分别为10.2%,40.7%。治疗组不良反应表现为一过性头晕、嗜睡、记忆力减退、少言无语等。结论托吡酯治疗神经痛安全有效,可作为治疗神经痛的首选镇痛药物之一。
Objective To survey the clinical therapeutic effectivencss and security of topiramate (TPM) in the treatment of patients with neuralgia. Methods 118 patients with different kinds of neuralgia including greater occipital nerve neurolgia, spinal nerve neuralgia, sciatica etc. were randomly divided into 2 equal groups: the trial group and control group . Patients of the trial group were given each 25 or 50 mg of TMP PO,b. i, d, , while those of the control group were given each 100mg ,of carbamazepine (CBZ) PO, b. i. d. or t. i. d.. The medication was continued for 1 more week after the pain had been relieved. The clinical therapeutic effectiveness of the drugs was assessea after the 2 week treatment. Results The overall effective rates in patients treated with TPM aud CBZ were 93.2%, and 86.4%, respectively ( P 〈 0.05 ). The incidences of adverse reactions in patients treated with TPM and CBZ were 10.2% and 40.7% , respectively. Adverse reactions encountered in patients treated with TPM included transient dizziness, somnolence, hypomnesis and hypologia. Conclusion TPM was shown to be effective and safe in the treatment of neuralgia and may be regarded as one of the first choice analgesics in the treatment of the disease.
出处
《医药导报》
CAS
2006年第12期1278-1279,共2页
Herald of Medicine
关键词
托吡酯
卡马西平
神经痛
Topiramate
Carbamazepine
Neuralgia