RANKL-RANK-OPG骨调节轴

The Bone Regulating Axle of RANKL-RANK-OPG

核因子kB受体活化因子配基(receptoractivatorofNF-kBLigand,RANKL)是一种型跨膜蛋白,是目前发现的惟一具有诱导破骨细胞分化、发育、发挥功能的因子;NF-kB受体激活子(receptoractivatorofNF-kB,RANK)是一种型跨膜蛋白,是RANKL的惟一受体,是RANKL发挥功能的关键;骨保护蛋白(osteoprotegerin,OPG)是一种分泌型糖蛋白,与RANKL竞争性与RANK结合抑制骨吸收、促进骨形成。RAN-KL、RANK、OPG形成RANKL-RANK-OPG骨调节轴,是影响破骨细胞分化、发育、调节其功能惟一的、最终的途径,不仅在多种骨质疏松的发病中起重要作用,而且也为骨质疏松的治疗开辟了广阔的前景。

The receptor activator ot NF-kB hgand （RANKL）,one of tne type Ⅱ trans- membrane glyeoprotein, is the only factor found to induce the, differentiation, maturation of osteoclastgenesis and mediating its function. Receptor activator of NF-kB （RANK）,a type Ⅰ trans-membrane glycoprotein,is the unique receptor of RANKL, which plays a key role in RANKL-mediated osteoclastgenesis and function. Osteoprotegerin （OPG）- a secretory glycoprotein,inhibits the RANKL mediated bone absorption and promotes the bone formation by competitively combining with RANK. Therefore, RANKL RANK-OPG,which is the only and ultimate means to affect the differentiation,maturation of osteoclastgenesis and regulate its functions, forms an axle to regulate the bone model and remodel. The disorder of RANKL RANK-OPG axle not only plays an important role in osteoporosis but also gives rise to a broader prospect for osteoporosis treatment.