老年患者医院感染阴沟肠杆菌和鲍曼不动杆菌耐药性分析

The antimicrobial resistance in Enterobacter cloacae and Acinetobacter baumannii causing nosocomial infection in senile patients

目的了解老年患者医院感染阴沟肠杆菌和鲍曼不动杆菌的耐药性。方法对我院2004～2005年>60岁患者发生阴沟肠杆菌57～70株和鲍曼不动杆菌86～133株感染者用WHONET-5.3软件进行分析总结。结果阴沟肠杆菌对10种抗生素的耐药率为:亚胺培南0～1.1%,哌拉西林/他唑巴坦43.0%～77.0%,头孢哌酮/舒巴坦58.0%～68.0%,头孢噻肟90.0%～74.0%,头孢他啶57.0%～80.0%,氨曲南91.0%～76.9%,头孢吡肟64.0%～70.0%,环丙沙星63.0%～75.0%,左氧氟沙星60.0%～85.7%,阿米卡星50.0%～78.3%。鲍曼不动杆菌对10种抗生素的耐药率为:亚胺培南1.2%～2.4%,哌拉西林/他唑巴坦41.2%～46.8%,头孢哌酮/舒巴坦27.1%～29.5%,头孢噻肟71.1%～71.4%,头孢他啶51.5%～63.4%,氨曲南57.1%～84.3%,头孢吡肟34.3%～48.9%,环丙沙星59.3%～54.6%,左氧氟沙星38.8%～47.7%,阿米卡星64.6%～58.5%。结论我们必须对阴沟肠杆菌和鲍曼不动杆菌引起的老年患者医院感染的临床治疗给予更多的重视。

Objective To investigate the antimicrobial resistance in Enterobacter cloacae and Acinetobacter baumannii causing nosoeomial infection （NI） in senile patients. Methods 57-70 strains of Enterobacter cloacae and 88- 133 strains of Aeinetobacter baumannii causing NI in senile patients （aged〉60） reported in our hospital during 2004 and 2005 were analyzed with WHONET-5.3 software. Results During the period studied, the prevalence of antimicrobial resistance in Enterobaeter cloacae to 10 antibiotics was： Imipenem 0%-1.1%, Piperacillin / Tazobaetam 43.0%-77.0%, Cefoperazone/Sulbactam 58.0%-68.0%, Cefotaxime 90.0%-74.0%, Ceftazidime 57.0%-80.0%, Aztreonam 91.0%- 76.9%, Cefepime 64.0%-70.0%, Ciprofloxacin 63.0%-75.0%, Levofloxacin 60.0%-85.7% and Amikacin 50.0%- 78.3%; the antimicrobial resistance in Acinetobacter baumannii to 10 antibiotics was： Imipenem 1.2%-2.4%, Piperacillin/ Tazobactam41.2%-46.8%, CefoperazoneSulbactam27.1%-29.5%, Cefotaxime71.1%-71.4%, Ceftazidime51.5%-63.4%, Aztreonam 57.1%-84.3%, Cefepime 34.3%-48.9%, Ciprofloxacin 59.3%-54.6%, Levofloxacin 38.8%-47.7% and Amikacin 64.6%-58.5%. Conclusion Nosocomial infections caused by Enterobacter cloacae and Acinetobacter baumannii in senile patients should justify more clinical attention.