血液透析患者颈动脉硬化与血清脂联素水平的关系

The relationship of carotid atherosclerosis and serum adiponectin level in hemodialysis patients

目的探讨维持性血液透析(MHD)患者颈动脉硬化与血清脂联素(ADPN)水平的相关性。方法对首都医科大学附属北京朝阳医院肾内科40例维持性血液透析患者运用B超检查测定颈总动脉硬化情况,根据有无颈动脉硬化分为颈动脉正常组和颈动脉硬化组;同时采用酶联免疫法测定患者血清的ADPN水平,并与20例年龄和性别相当的健康体检者(对照组)进行比较。结果MHD组血清ADPN水平普遍高于于正常对照组,但是颈动脉硬化组血清ADPN水平低于颈动脉正常组;相关分析发现,血清ADPN与颈动脉硬化呈显著负相关性。结论MHD患者颈动脉硬化发生率明显高于正常人,颈动脉硬化发生率与血浆ADPN存在着相关性,ADPN可能参与颈动脉硬化的发生发展过程,测定血浆ADPN为评价MHD患者颈动脉病变程度提供了一条新的线索。

Objective To study the relationship between carotid atherosclerosis and serum adiponectin（ADPN） level in hemodialysis patients. Methods The right carotid intima media thickness （IMT） were studied by B-model ultrasound and plasma ADPN were detected in 40 maintenance hemodialysis patients （HD group） as well as in 20 healthy individuals （control group）. Results The serum ADPN level was significantly higher in hemodialysis group than in control group; But the ADPN level of carotid atherosclerosis group was lower than in normal carotid group. The relative analysis showed that there severity of carotid atherosclerosis was nega tively correlated with serum ADPN level. Conclusion The probability of carotid atherosclerosis in hemodialysis patients is thicker higher than healthy individuals. We concIuded carotid atherosclerosis is related to correlated with serum ADPN. ADPN may participate in the development of carotid atherosclerosis, To measure serum ADPN will give us provide a new method to estimate the degree of carotid pathological changes in hemodialysis patients.