小剂量尿激酶治疗频发短暂性脑缺血发作临床研究

A clinical study of small-dose urokinase in the treatment of frequent transient ischemic attack

目的 研究小剂量尿激酶对频发的短暂性脑缺血发作（TIA）的疗效。方法 将64例频发的TIA患者随机分为治疗组和对照组。治疗组在对照组治疗的基础上加用小剂置尿激酶静脉点滴，连续5．7d。结果 治疗组治疗后24h内及72h内TIA发作控制率分别是71．9％和93．8％，均高于对照组18．8％和50％（P〈0．01）；且治疗组血浆粘度和纤维蛋白原较对照组明显降低（IP〈0．01）。结论 小剂量尿激酶治疗频发TIA疗效显著、安全、见效快，且能有效防止脑梗死的发生。

Objective：To study the clinical effect of small -dose urokinase in the treatment of frequent transient ischemic attack （ TIA ）. Methods ： Sixty - four patients with TIA were randomly divided into study group and control group. The study group added small - dose urokinase to ivdrip for 5 - 7 days in the base of the treatment of the control group. Results ： The control rates to attack of the study group were respectively 71.9% and 93.8% within twenty - four hours and seventy - two hours after treatment, they were higher than 18.8% and 50% of the control group （ P 〈0.01 ） ;and the fibrinogen and serous mucosity of the study group were significantly lower than the control group （ P 〈 0. 01 ）. Conclusion ： Small - dose urokinase is effective and safe in the treatment of frequent TIA, and it can effectively prevent cerebtral infarction.