体外冲击波碎石前后机体内皮素的变化和钙离子拮抗剂对肾损害的防护作用

The experimental study on changes of endothelin before and after extracorporeal shock wave lithotripsy and protective effects of entry blocker

将36只家兔随机分为三组,A组:15只,未用异搏定;B组:15只,异搏定处理;C组:6只,正常对照。A和B组予体外冲击波碎石(ESWL),观察ESWL前后血、尿和肾组织中内皮素的变化。结果A组ESWL后1、3天尿和肾组织中内皮素显著升高,B组ESWL后1天尿内皮素轻度升高,而两组血中内皮素无明显变化。提示ESWL后早期机体内皮素升高可能与肾损害有关,异搏定可抑制内皮素的升高,减轻肾损害。

Changes of endothelin before and after extracorporeal shock wave lithotrip- sy were observed. Thirty six rabbits were ran- domly divided into 3 groups. In group A n= 15, verapamil was given; in group B n=15, no verapamil was given and 3 group C n= 6served as control. In group B, a significant el- evation of endothelin was found in blood, urine and renal tissue on the 1 st and/or the 3rd day after ESWL, and in group A, only slight change was detected. In the early elevation of endothelin after ESWL might have something to do with renal damage. Verapamil may in- hibit the synthesis and release of endothelin, thereby lessening renal damage and improving renal function.