黄体期避孕对月经影响的临床研究

Clinical Study of the Influence of Contraception in Lteal Phase on Menstruation

目的：评估当妇女在月经周期有无保护性生活超过120h，或多次无保护性生活后于黄体期避孕对月经的影响。方法：在黄体期1次性服用米非司酮100mg并在36—48h后服用米索前列醇400μg，服药后观察月经情况。结果：100例受试者中4例妊娠，在成功避孕的96例中，月经提前68例（70．83％），延期15例（15．6％），无改变13例（13．5％）。服药前后比较，月经周期缩短，差异有显著性意义（P〈0．01），服药后川经出血天数5．76±1．18天，与妇女原来出血天数比较差异有显著性意义（P〈0．05），与服药前自身经量比较，经量减少1例，相似90例，增多5例，经量与服药前差异无娃著性意义（P〉0．05）。服药距下次月经时间为6．85±1．88天，服药距下次月经9～7天组和6～4天组月经周期缩短，与服药前相比差异均有嶷著性意义（P〈0．05），而3～1天组月经周期改变／不明显（P〉0．05）；出血天数及经量3组间无显著性差异（P〉0．05）。结论：黄体期避孕有效率为96％，该方法可使妇女月经周期缩短，经期延长，且服药距下次月经时间长对月经周期影响较大。

Objective ： To observe the influence of contraception in luteal phase on menstruation. Methods ： The sequential mifepristone - misoprostol regimen used 100mg oral dose of mifepristone followed 36 - 48hours later by 0.4mg oral dose misopristol, The menstrual status was observed after treatment. Results ： The present results showed that menstrual cycle was 27.56days and 28.87days after and before treatment, respectively. It showed significant difference in menstrual cycle between two groups （P 〈 0.01 ） . The menstrual bleeding day was 5.76 days and 5.42 days after and before treatment respectively. The menstrual bleeding day was increased significantly after treatment （ P 〈0. 05 ）. Conclusions ： The sequential regiment can decrease menstrual cycle and increase menstrual bleeding day during the luteal phase to the contracep- tion and the initial time of treatment with sequential regimen in luteal phase can influence menstrual cycle.